TIM-1在病毒相关疾病中的研究进展

Research progress of TIM-1 in virus-related diseases

TIM-1基因是TIM基因家族中首个被发现的分子,其编码的蛋白质是一种膜表面糖蛋白。近年研究表明TIM-1蛋白能够显著提高多种致病性病毒的感染效率,其可以通过与暴露在病毒和宿主细胞膜上的磷脂酰丝氨酸残基结合,与包膜病毒和凋亡细胞发生类似的相互作用,促进不同家族包膜病毒的感染。TIM-1 IgV结构域和黏蛋白样结构域也在病毒感染中起关键作用。因此,TIM-1可能成为病毒感染的新靶点。本文对TIM-1分子在病毒感染相关疾病中的研究进展进行综述。

Objective:TIM-1 gene is the first molecule to be discovered in the TIM gene family.The protein it encodes is a membrane surface glycoprotein.Recent studies have shown that TIM-1 protein can significantly improve the infection efficiency of many pathogenic viruses.It can promote the infection of different families of enveloped viruses by binding to phosphatidylserine residues exposed to the virus and host cell membranes and having similar interactions with enveloped viruses and apoptotic cells.The IgV domain and mucoprotein domain of TIM-1 also play a key role in viral infection.Therefore,TIM-1 may be a new target for antiviral infection therapy.This article reviews the research progress of TIM-1 in viral infection-related diseases.