TRIM21在病毒诱导的天然免疫应答中的研究进展

Research progress of TRIM21 in virus-induced natural immune response

三结构域蛋白21(TRIM21)是TRIM家族中的一员,其作为E3泛素连接酶在抗病毒天然免疫中发挥了重要作用。当病毒入侵时,TRIM21与病毒核酸感受器介导的抗病毒信号通路中的关键蛋白相互作用,泛素化IRF3、IRF5、IRF7、IRF8、MAVS、DDX41等调控和维持机体的抗病毒稳态。TRIM21在机体内还介导抗体依赖的细胞内中和反应,协同补体系统发挥抗病毒效应。本文主要就当前TRIM21作为E3泛素化酶在病毒诱导的天然免疫应答中的研究进展进行归纳和阐述。

Tripartite motif 21(TREM21)is a member of TRIM protein family.As an E3 ubiquitin ligase,TRIM21 plays an important role in anti-viral innate immune response.When virus invade,TRIM21 interacts with some key proteins in the anti-viral signal pathway initiated by the virus nucleic acid receptors,then promotes the ubiquitination of IRF3,IRF5,IRF7,IRF8,MAVS,DDX41 and so on,to maintains the homeostasis of internal environment.TRIM21 also mediates antibody-dependent intracellular neutralization in vivo,which cooperates with complement system to exert antiviral effect.In this paper,we focus on the research progress of TRIM21 as an E3 ubiquitinase in virus-induced innate immune response.