激光散斑成像实时评估小鼠颈动脉血栓模型

Real-time Evaluation of Mouse Carotid Thrombosis Model by Laser Speckle Imaging

血栓是造成心肌梗死和脑卒中的重要因素,血栓形成机制和溶栓药物仍是研究热点。在机制和药物研究中,常以动物模型为基础,多采用激光多普勒和超声多普勒技术监测血流信号以评估血栓的形成和影响。使用激光散斑成像技术对小鼠右侧颈动脉血栓造模进行实时监测,实现了FeCl3溶液处理后稳定的血栓形成,为血栓的动物模型研究提供了新的成像工具和方法。

Thrombosis is an important factor that causes myocardial infarction and stroke.The mechanism of thrombosis and therapeutic drugs are still challenging in research.Basic studies of mechanisms and drugs often utilized animal models.Laser Doppler and ultrasound Doppler techniques are often used to monitor blood flow signals to assess the formation and impact of thrombosis.In this study,laser speckle imaging technology is used to monitor the right carotid artery thrombosis in mice in real time,and stable thrombosis was achieved after 175s of FeCl3 solution treatment.This study provides new imaging tools and methods for animal model research of thrombosis.