噻托溴铵辅助舒利迭吸入对稳定期COPD患者肺功能和运动耐量的影响

Effects of Tiotropium Bromide in Combination with Seretide on Pulmonary Function and Exercise Tolerance in Patients with Stable COPD

目的探究噻托溴铵辅助舒利迭吸入对稳定期慢性阻塞性肺疾病(COPD)患者肺通气功能、运动耐量及呼吸困难症状的影响。方法选取我院2017年1月—2018年12月收治的90例稳定期COPD患者作为研究对象,按随机数字表法分为对照组45例和观察组45例。对照组采用舒利迭吸入治疗,观察组采用噻托溴铵辅助舒利迭吸入治疗,比较两组肺功能、运动耐量和呼吸困难症状。结果治疗3个月后,对照组和观察组患者FEV1、FEV1%、FEV1/FVC水平均高于同组治疗前,且观察组高于对照组(P均<0.05)。治疗3个月后,两组患者6MWT均高于治疗前,mMRC评分低于治疗前(P均<0.05),且观察组6MWT高于对照组,mMRC评分低于对照组(P均<0.05)。结论噻托溴铵辅助舒利迭吸入治疗稳定期COPD患者,对患者呼吸困难、运动耐量以及肺功能的改善作用明显。

Objective To investigate the effects of tiotropium bromide assisted seretide inhalation on pulmonary ventilation function,exercise tolerance and dyspnea symptoms in patients with stable chronic obstructive pulmonary disease(COPD). Methods Ninety cases of COPD patients admitted and treated in our hospital from January 2017 to December 2018 were selected as research objects,and were divided into 45 cases of control group and 45 cases of observation group according to the numerical random table method. The control group was treated with seretide inhalation,and the observation group was treated with tiotropium bromide assisted seretide inhalation. Pulmonary function,exercise tolerance and dyspnea symptoms were compared between the two groups. Results After 3 months of treatment,the levels of FEV1,FEV1% and FEV1/FVC in two groups were higher than those in the same group before treatment,and those in the observation group were higher than those in the control group(P<0.05). After 3 months of treatment,6 MWT and m MRC scores in both groups were improved compared with those before treatment,and the observation group’s 6 MWT scores were higher than those in the control group and m MRC scores were lower than those in the control group(P<0.05). Conclusion Tiotropium bromide assisted inhalation of seretide in the treatment of stable COPD patients,the improvement of dyspnea,exercise tolerance and lung function is significant.