介导糖尿病肾病线粒体损伤的相关信号通路

Signaling pathways involved in mediating mitochondrial damage in diabetic kidney disease

糖尿病(diabetes mellitus,DM)是一组由于胰岛素的作用和(或)分泌缺欠而引起的以慢性高血糖和葡萄糖不耐受为主要特征的代谢性综合征。根据世界糖尿病联盟统计,2017年糖尿病的世界发病率(20~79岁)为8.8%,预计到2045年会达到9.9%。2017年,中国大陆糖尿病患病率为10.9%,约有1.144亿糖尿病患者(20~79岁),位居世界第一,占世界糖尿病患者总数的1/4以上。

Diabetic kidney disease(DKD)is one of the most common and serious chronic complications of diabetes and has gradually become the main cause of end-stage renal disease(ESRD).As the center of energy and metabo lism in cells,mitochondria have become the focus of the research on the pathogenesis of DKD in recent years.Current studies find that damage to mitochondria,such as DNA mutations,structural damage,oxidative stress imbalance,etc,leads to apoptosis of kidney cells,thus causing the loss of kidney function.In the process of mitochondrial damage,a se ries of important signaling pathways are involved,and exploring these signaling pathways would help us better understand the pathogenesis of DKD and find new therapeutic targets.In this article,the important signaling pathways associated with mitochondrial damage are reviewed.