摘要
白细胞介素38(interleukin-38,IL-38)是IL-1家族(IL-1 family,IL-1F)中最新发现的细胞因子,隶属于IL-36亚家族。它最早由两个独立科研小组于2001年发现的,分别被命名为IL-1HY2和IL-1F10[1-2]。IL-38的编码基因位于人类染色体2q13-14.1上,编码IL-1受体拮抗剂(IL-1 receptor antago⁃nist,IL-1Ra)和IL-36Ra的基因之间[2]。
Interleukin-38(IL-38)is the most recently discovered cytokine of the IL-1 family and is an IL-36 receptor inhibitor.IL-38 is mainly expressed in human immune organs and associated with a variety of diseases.In the process of apoptosis and necrosis caused by injury or inflammation,researchers have studied quiet a lot about the kinase,cleavage sites,activity regulatory mechanism,signal transduction ligand,transduction mode and potential receptors of IL-38,but many mechanisms are still unknown.This article reviews the role of IL-38 in the pathogenesis and progression of lung tumors,asthma and interstitial lung disease.We also discussed the role of IL-38 in the treatment of these diseases,the possible relationship between IL-38 and tuberculosis,and the direction of future studies on the mechanism of IL-38 ac tion.
作者
徐唯傑
马俊
李明才
XU Wei-jie;MA Jun;LI Ming-cai(Medical School of Ningbo University,Ningbo 315211,China;Shanghai Pulmonary Hospital,Shanghai 200003,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2020年第9期1715-1720,共6页
Chinese Journal of Pathophysiology
基金
浙江省自然科学基金资助项目(No.LY17H010001,No.LY18H010003)。
关键词
白细胞介素38
肺癌
哮喘
间质性肺病
肺结核
Interleukin-38
Lung cancer
Asthma
Interstitial lung disease
Tuberculosis
