肝硬化临床终点事件的精准预测

Accurate prediction of clinical endpoints of liver cirrhosis

尽管根据病因治疗已经降低肝硬化并发症的发生率和病死率,但部分患者仍会出现疾病进展。实现肝硬化临床终点事件的精准预测并加强干预对于进一步降低病死率至关重要。为此,从肝组织病理学、无创性指标、影像学及方法学等方面共同探讨对肝硬化临床终点事件的预测,以提早筛选高风险人群,建立精准预测模型,帮助进一步减少肝硬化临床终点事件的发生。

Although etiological treatment has reduced the incidence and mortality rates of liver cirrhosis complications,some patients may still experience disease progression.It is of great importance for further reducing mortality rate to accurately predict the clinical endpoints of liver cirrhosis and strengthen intervention.Therefore,this article discusses the prediction of clinical endpoints of liver cirrhosis from the aspects of liver pathology,noninvasive markers,imaging,and methodology,in order to help with early screening of the high-risk population,establish accurate predictive models,and further reduce the incidence rate of clinical endpoints of liver cirrhosis.