他汀类药物在肝癌治疗中的“双刃剑”作用及相关机制探讨

Role of statins as a“double-edged sword”in treatment of liver cancer and related mechanisms

在过去十年中,甲羟戊酸途径及其抑制剂他汀类药物在预防肿瘤发生及改善肿瘤预后方面的作用得到了广泛关注。然而,到目前为止,他汀类药物在肝癌中的作用仍然存在争议。前期研究证实,他汀类药物在胆固醇代谢、抗氧化及抗炎方面发挥重要作用。而胆固醇代谢、氧化应激及炎症反应则是促进肝癌发生发展的重要因素。但最近也有研究发现,他汀药物在部分肝癌患者治疗中存在相反的作用。对他汀药物在肝癌治疗中的“双刃剑”作用及其相关分子机制进行了阐述。

In the past decade,the role of the mevalonic acid pathway and its inhibitor statins in preventing tumorigenesis and improving tumor prognosis has attracted wide attention;however,so far,there are still controversies over the role of statins in liver cancer.Previous studies have shown that statins play an important role in cholesterol metabolism,antioxidation,and anti-inflammation,and cholesterol metabolism,oxidative stress,and inflammatory response are important factors to promote the development and progression of liver cancer.However,some recent studies have found that statins have an adverse effect on the treatment of some liver cancer patients.This article elaborates on the role of statins as a“double-edged sword”in the treatment of liver cancer and related molecular mechanisms.