肿瘤相关中性粒细胞在肝癌发生发展中的调控作用

Regulatory effect of tumor-associated neutrophils in the development and progression of liver cancer

近年来肝癌的发病率仍在上升,早期诊断困难,治疗效果不好,预后差。叙述了肿瘤相关中性粒细胞参与调控肝癌肿瘤微环境的研究进展,指出其可以作为肝癌治疗的新靶点。结合肝细胞癌微环境中存在的肿瘤相关巨噬细胞、调节性T淋巴细胞和多种细胞因子等,可能会达到系统抗肿瘤的效果,为肝癌治疗带来曙光。

The incidence rate of liver cancer keeps increasing in recent years,and this disease has difficulties in early diagnosis,poor treatment outcome,and poor prognosis.This article describes the research advances in tumor-associated neutrophils involved in the regulation of liver tumor microenvironment and points out that they can be used as a new target for the treatment of liver cancer.Combined with tumor-associated macrophages,regulatory T cells,and various cytokines in liver tumor microenvironment,tumor-associated neutrophils can achieve a systemic anti-tumor effect and thus bring hopes to the treatment of liver cancer.