期刊文献+

原发性胆汁性胆管炎高危因素的研究进展 被引量:4

Research advances in high-risk factors for primary biliary cholangitis
下载PDF
导出
摘要 原发性胆汁性胆管炎(PBC)是一种由遗传易感性和环境触发因素共同作用引起的多因素疾病。在已知的发病危险因素中,环境因素主要通过对线粒体的免疫耐受产生破坏而引发疾病。而随着研究的深入,尤其是全基因组关联研究技术的应用,发现了一些可能导致该病的危险基因,如人类白细胞抗原基因IL和X染色体单体等。对PBC的高危因素如细菌、病毒感染以及遗传基础等方面的进展进行了阐述。 Primary biliary cholangitis(PBC)is a multifactorial disease caused by the combined effect of genetic susceptibility and environmental triggers.Among the known risk factors for PBC,environmental factors mainly cause the onset of the disease by disrupting mitochondrial immune tolerance.With the deepening of research,especially the application of genome-wide association study technology,some dangerous genes have been found,such as human leukocyte antigen gene IL and X chromosome monomer.This article reviews the research advances in high-risk factors for PBC.
作者 廖海玲 杨晋辉 LIAO Hailing;YANG Jinhui(Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China)
出处 《临床肝胆病杂志》 CAS 北大核心 2020年第9期2125-2128,共4页 Journal of Clinical Hepatology
关键词 胆管炎 硬化性 危险因素 cholangitis,sclerosing risk factors environmental factors heredity factors
  • 相关文献

参考文献2

二级参考文献132

  • 1Abdulkarim SS, Petrovic LM, Kim WR, et al. Primary biliary cirrhosis:an infectious disease caused by Chlamydia pneumonia (abstract)?Gastroenterology, 2002, 122: A550.
  • 2Shoenfeld Y, Sherer Y, Harats D. Artherosclerosis as an infectious,inflammatory and autoimmune disease. Trends Immunology, 2001,22: 293-295.
  • 3Layh Schmitt G, Bendl C, Hildt U, et al. Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis. Ann Neurol, 2000, 47: 652-655.
  • 4Ponsioen CY, Defoer J, Ten Kate FJ, et al. A survey of infectious agents as risk factors for primary sclerosing cholangitis: are Chlamydia species involved? Eur J Gastroenterol Hepatol, 2002, 14: 641-648.
  • 5Bachmaier K, Neu N, de la Maza LM, et al. Chlamydia infections and heart disease linked through antigenic mimicry. Science, 1999,283: 1335-1339.
  • 6Du C, Yao SY, Ljunggren Rose A, et al. Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitis. J Exp Med, 2002, 196: 1639-1644.
  • 7Catrina AI, Deane KD, Scher JU. Gene, environment, microbiomeand mucosal immune tolerance in rheumatoid arthritis.Rheumatology (Oxford) 2014; Epub ahead of print [PMID:25539828 DOI: 10.1093/rheumatology/keu469].
  • 8El-Fawal HA. Neuroantibody biomarkers: links and challengesin environmental neurodegeneration and autoimmunity.Autoimmune Dis 2014; 2014: 340875 [PMID: 25045531 DOI:10.1155/2014/340875].
  • 9Ellis JA, Kemp AS, Ponsonby AL. Gene-environment interactionin autoimmune disease. Expert Rev Mol Med 2014; 16: e4 [PMID:24602341 DOI: 10.1017/erm.2014.5].
  • 10Somers EC, Richardson BC. Environmental exposures, epigeneticchanges and the risk of lupus. Lupus 2014; 23: 568-576 [PMID:24763540 DOI: 10.1177/0961203313499419].

共引文献8

同被引文献62

引证文献4

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部