原发性胆汁性胆管炎高危因素的研究进展

Research advances in high-risk factors for primary biliary cholangitis

原发性胆汁性胆管炎(PBC)是一种由遗传易感性和环境触发因素共同作用引起的多因素疾病。在已知的发病危险因素中,环境因素主要通过对线粒体的免疫耐受产生破坏而引发疾病。而随着研究的深入,尤其是全基因组关联研究技术的应用,发现了一些可能导致该病的危险基因,如人类白细胞抗原基因IL和X染色体单体等。对PBC的高危因素如细菌、病毒感染以及遗传基础等方面的进展进行了阐述。

Primary biliary cholangitis(PBC)is a multifactorial disease caused by the combined effect of genetic susceptibility and environmental triggers.Among the known risk factors for PBC,environmental factors mainly cause the onset of the disease by disrupting mitochondrial immune tolerance.With the deepening of research,especially the application of genome-wide association study technology,some dangerous genes have been found,such as human leukocyte antigen gene IL and X chromosome monomer.This article reviews the research advances in high-risk factors for PBC.