摘要
病毒与非病毒因素引起的肝损伤是慢性肝病的重要阶段,肝损伤的发生机制仍是目前研究的热点。随着对肠道菌群研究的深入,大量证据表明,肠道菌群参与了肝损伤的发生、发展,研究证实嗜黏蛋白阿克曼氏菌(Akk菌)对肝损伤具有有益作用。总结了Akk菌在免疫介导的肝损伤、酒精性肝病、非酒精性脂肪性肝病中的作用及潜在机制,认为其可为肝损伤的预防及治疗提供新的方向和选择。
Liver injury caused by viral and non-viral factors is an important stage of chronic liver disease,and the pathogenesis of liver injury is still a research hotspot.With the deepening of the research on gut microbiota,substantial evidence indicates that gut microbiota participates in the development and progression of liver injury,and it has been confirmed that Akkermansia muciniphila(Akk)has a beneficial effect against liver injury.This article summarizes the role and potential mechanism of Akk in immune-mediated liver injury,alcoholic liver disease,and nonalcoholic fatty liver disease.It is believed that Akk may provide new directions and choices for the prevention and treatment of liver injury.
作者
刘利敏
姚明解
胡端敏
LIU Limin;YAO Mingjie;HU Duanmin(Department of Gastroenterology,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215000,China;Department of Gastroenterology,Yancheng First People’s Hospital,Yancheng,Jiangsu 224001,China;Department of Anatomy and Embryology,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第9期2133-2136,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金资助项目(81902115)
中国博士后科学基金(2017M620544,2018T110014)。
