HLA-G对子痫前期发生发展的影响

Effect of HLA-G on development of preeclampsia

子痫前期(PE)是一种常见的妊娠特有并发症,其病因及发病机制与免疫因素有关,而人类白细胞抗原G(HLA-G)在母胎免疫调节中发挥重要作用。HLA-G具有启动子独特性及限制多态性两种基因特性,胎儿滋养细胞HLA-G分子低表达是介导PE发生的关键环节,可能由细胞胞啃机制受阻、获取HLA-G能力下降所致,继而通过Th1/Th2平衡向Th1偏移、滋养细胞浸润能力受损,造成胎盘浅着床和子宫螺旋动脉重铸不足,促进PE的发生发展。

Preeclampsia(PE)is a common pregnancy-specific complication,which etiology and pathogenesis are related to immune factors,and human leukocyte antigen G(HLA-G)plays an important role in maternal-fetal immune regulation.HLA-G has two gene characteristics:promoter uniqueness and restriction polymorphism,the low expression of HLA-G molecule in fetal trophoblasts is a key link in mediating the development of PE,which may be caused by the blocked cell cytoplasmic mechanism and the decreased ability acquiring HLA-G,then through Th1/Th2 balance shifts to Th1 and trophoblastic infiltration ability is impaired,resulting in placental shallow implantation and insufficient recasting of the uterine spiral artery,promoting the development of PE.