子宫上皮样滋养细胞肿瘤一例报告并文献复习

A Case Report of Epithelioid Trophoblastic Tumor and Literatures Review

上皮样滋养细胞肿瘤(epithelioid trophoblastic tumor,ETT)是一种罕见的恶性妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN),约占GTN的1.39%~2%,多见于育龄妇女,常继发于足月妊娠,临床表现缺少特异性,给诊断带来极大的困难,明确诊断主要依据病理。治疗手段主要是手术、化疗及局部放疗,无统一治疗方案,需个体化处理。不良预后因素目前尚不明确,主要包括子宫外病灶、距离前次妊娠时间超过4年等;无转移者预后良好,有转移者预后极差。

Epithelioid trophoblastic tumor(ETT)is a rare gestational trophoblastic neoplasia(GTN),accounting for 1.39%-2%of GTN.ETT occurs mostly in women of childbearing age,especially after full-term pregnancy.The clinical manifestations are of nontypical,and the definite diagnosis is mainly based on the histopathologic examination.Surgery is the preferred option for the treatment of ETT,and the effect of chemotherapy and local radiotherapy remains controversial and individual.The factors of ETT prognosis are ambiguous,including the extra-uterinelesion the interval over 4 years from the antecedent pregnancy.The prognosis could be better in patients without metastasis,but very poor in those patients with metastasis.