TET3在生殖配子发生和胚胎发育中的调控作用

Roles of TET3 in Regulating Gametogenesis and Embryonic Development

TET3(ten-eleven translocation 3)属于TET家族成员,是一种依赖于Fe2+和α-酮戊二酸(α-ketoglutarate,α-KG)的双加氧酶,可以把5-甲基胞嘧啶(5-mC)氧化为5-羟甲基胞嘧啶(5-hmC),介导DNA的去甲基化,以完成对基因表达的调控。研究显示TET3不仅在神经分化中上调表达,而且在配子发育中持续表达,并对早期胚胎的发育激活起到重要作用,揭示TET3介导的基因表达调控对哺乳动物的生殖发育具有一定影响。现对TET3的蛋白结构、在配子和胚胎发育中的调控作用以及TET3相关的生物学功能等进行综述,以促进TET3的功能研究及其在生命科学领域中的应用。

Ten-eleven translocation 3(TET3),one member of TET family,is a dioxygenase that depends on Fe2+andα-ketoglutarate(α-KG).TET3 can oxidize 5-methylcytosine(5-mC)to 5-hydroxymethylcytosine(5-hmC)and complete the regulation of gene expression.Studies showed that the expression of TET3 was not only up-regulated during neural differentiation,but also sustained during gametogenesis,and that TET3 played an important role in regulating the early embryonic development and activation.In other words,the TET3-mediated gene expression and regulation are involved in the mammalian reproduction and embryonic development.The structure of TET3 protein,the roles of TET3 in regulating gametogenesis and embryonic development,and other TET3-related biological functions,were reviewed in this paper,so as to promote the functional research of TET3 and the application in the field of life sciences.