长链非编码RNA与多囊卵巢综合征关系的研究进展

Research Progress on the Relationship between Long Non-Coding RNA and Polycystic Ovary Syndrome

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是临床常见的生殖内分泌疾病,发病率逐年增高。PCOS的发生发展与多种因素有关,其中遗传因素可能起着关键作用。长链非编码RNA(long noncoding RNA,lncRNA)是指长度超过200个核苷酸而不参与蛋白质编码功能的一类RNA,其活性改变与生长发育、细胞增殖、分化和凋亡息息相关。越来越多的研究表明lncRNA与PCOS有关,在性激素分泌、胰岛素抵抗、卵泡发育、颗粒细胞增殖与凋亡中发挥作用,几乎参与了PCOS发生发展的各个环节。综述近年来lncRNA与PCOS相关研究进展,希望能为PCOS的诊断和治疗研究提供新的思路。

Polycystic ovary syndrome(PCOS)is a common clinical reproductive endocrine disease,and the incidence increases year by year.The pathogenesis of PCOS is related to many factors,in which the genetic factor may play a key role.Long non-coding RNA(lncRNA)refers to a kind of RNAs whose length exceeds 200 nucleotides.Although lncRNAs do not participate in the translation of protein,the activites of lncRNAs and the changes of activities are closely related to the growth and development,cell proliferation,differentiation and apoptosis.More and more studies have shown that lncRNAs are related to the pathogenesis of PCOS.lncRNAs may play some roles in the sex hormone secretion,insulin resistance,follicular development,granulosa cell proliferation and apoptosis,suggesting that lncRNAs almost participate in all aspects of PCOS development.This article reviews the recent research progress of lncRNAs in the pathogenesis of PCOS,to provide new ideas for the diagnosis and treatment of PCOS.