长链非编码RNA在卵巢癌中表达模式的研究进展

Expression Patterns of Long Non-Coding RNAs in Ovarian Cancer and Possible Application

卵巢癌是死亡率最高的妇科癌症之一。开发有效的用于诊断和预后的生物标志物对于新的治疗靶点和延长卵巢癌患者的生存时间至关重要。长链非编码RNAs(long non-coding RNAs,lncRNAs)是近年发现的一类非编码转录本,参与多种疾病的发生和发展。部分lncRNAs已被证实在卵巢癌中发挥关键性功能作用,并可作为个体化药物的靶向治疗的依据。本文总结了lncRNAs的基本结构、功能、定位、分类及研究方法,阐述了几种lncRNAs在卵巢癌中的差异表达模式与卵巢癌细胞增殖、分化、侵袭及治疗反应之间存在的关联。此外,本文探讨了lncRNAs作为卵巢癌治疗靶点和改善化疗耐药性的潜在应用价值。

Ovarian cancer is one of the most lethal gynecological cancers.The development of useful biomarkers for the diagnosis and prognosis of ovarian cancer is essential for new targeted therapies and prolonging the survival time.Long non-coding RNAs(lncRNAs),a kind of non-coding transcripts which have been emerging recently,are involved in the occurrence and development of various diseases.Some LncRNAs have been proved to play a key functional role in ovarian cancer,which is the basis of targeted therapy of individualized drugs.In this article,the basic structure,function,localization and classification of lncRNAs,as well as the research methods,were summarized,and the relationship between the different expression patterns of lncRNAs in ovarian cancer and the proliferation,differentiation,invasion and treatment response of ovarian cancer cells was expounded.In addition,the potential value of lncRNAs as a therapeutic target for ovarian cancer,so as to improve chemotherapy resistance,was also discussed.