Introduction to special topic on exercise and oxidative stress

The discovery that endurance exercise is associated with oxidative stress was first reported in 1978.In the ensuing 4 decades,many studies confirmed this original observation.Recent investigations provided mechanistic insight into the sites of reactive oxygen species(ROS)production during exercise and the cellular consequences of an increase in ROS production.In this special topic of the Journal of Sport and Health Science,we feature 4 state-of-the-art reviews on key topics linking exercise and oxidative stress.