三花飞扬溶液治疗妊娠湿疹临床疗效观察

Clinical Observation of External Application of Sanhua Feiyang Solution in Treatment of Eczema of Pregnancy

【目的】观察外用三花飞扬溶液治疗妊娠湿疹的临床疗效。【方法】将60例妊娠湿疹患者随机分为试验组和对照组,每组各30例。试验组给予三花飞扬溶液外洗治疗,对照组给予炉甘石洗剂外洗治疗,疗程为4周,并随访4周。观察2组患者治疗前后湿疹面积及严重指数(EASI)评分和皮肤病生活质量指数量表(DLQI)评分的变化情况,评价2组的临床疗效、复发情况及安全性。【结果】(1)治疗过程中,试验组有1例患者因早产而剔除,最终纳入29例;对照组有1例患者失访,2例患者因自行停止治疗而剔除,最终纳入27例。(2)治疗4周后,试验组的总有效率为93.10%(27/29),对照组为77.78%(21/27),试验组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的EASI评分和DLQI评分均较治疗前明显降低(P<0.05),且试验组的降低作用均明显优于对照组,差异均有统计学意义(P<0.01)。(4)随访4周,试验组的复发率为3.70%(1/27),明显低于对照组的33.33%(7/21),差异有统计学意义(P<0.05)。(5)治疗期间,除对照组有5例患者出现皮肤干燥和紧绷感等不适外,其余患者均无明显不良反应情况发生。【结论】三花飞扬溶液治疗妊娠湿疹疗效确切,能有效改善患者湿疹症状,提高患者生活质量,其疗效优于炉甘石洗剂,且复发率低,安全性高。

Objective To evaluate the clinical efficacy of external application of Sanhua Feiyang Solution in the treatment of eczema of pregnancy. Methods By using the method of random number,60 patients with eczema of pregnancy were randomly divided into trial group(n = 30)and control group(n = 30). The trial group was treated with external application of Sanhua Feiyang Solution and the control group was given external application of calamine lotion. The patients were treated for 4 weeks and were followed up for another 4 weeks. Before and after treatment,the scores of eczema area and severity index(EASI)and dermatology life quality index(DLQI)in the two groups were observed. After treatment,the clinical efficacy and safety and the recurrence rate were compared between the two groups. Results(1)During the trial,one case from the trial group dropped out for premature birth,and a total of 29 cases in the trial group completed the trial. In the control group,one case lost to the follow-up,2 cases were excluded for their suspension of the treatment,and a total of 27 cases completed the trial.(2)After4 weeks of treatment,the total effective rate of the trial group was 93.10%(27/29),and the total effective rate of the control group was 77.78%(21/27). The clinical efficacy of the trial group was superior to that of the control group,and the difference was statistically significant(P<0.05).(3)After treatment,the EASI scores and DLQI scores of the two groups were obviously decreased in comparison with those before treatment(P<0.05),and the trial group had stronger effect on decreasing the EASI scores and DLQI scores than the control group, the differences being statistically significant(P<0.01).(4) The results of 4-week follow-up showed that the recurrence rate of the trial group was 3.70%(1/27),much lower than that of the control group(33.33%,7/21),and the difference was statistically significant(P<0.05).(5)During the trial,except that 5 cases from the control group had the sense of dryness and tightness in the skin,no other obvious adverse reaction was found in the two groups. Conclusion Sanhua Feiyang Solution exerts certain effect for the treatment of eczema of pregnancy by relieving the symptoms and increasing the quality of life. The solution is more effective and safer than calamine lotion with lower recurrence rate.