光学相干断层扫描血管成像在糖尿病微血管病变中的应用

The application of optical coherence tomography angiography in diabetic microangiopathy

糖尿病视网膜病变(DR)和糖尿病肾病(DN)是糖尿病患者最常见、最严重的两大微血管并发症,是引起致盲和终末期肾病的主要原因。视网膜血管是糖尿病早期常见的损害靶点,也是人体血管系统中唯一可直视的活体血管,其形态结构或功能的变化可直接或间接反映糖尿病引起的微血管病变。特别是近年来光学相干断层扫描血管成像(OCTA)这一新型、无创技术的发展,在血管成像分辨率、血管深度以及血管形态方面都有新的突破,并能提供客观的定量数据,在糖尿病微血管病变中具有一定应用价值。因此,本文旨在对OCTA及其在糖尿病微血管病变中的应用作一综述。

Diabetic retinopathy and diabetic nephropathy are the two most common and serious microvascular complications in diabetic patients,and they are the main causes of blindness and end-stage renal disease.Retinal blood vessels are the common damage targets of early diabetes and the only living blood vessels in the human vascular system that can be directly observed in naked eye.The changes in their morphological structure or function directly or indirectly reflect the microvascular lesions caused by diabetes.Especially,in recent years,the development of optical coherence tomography angiography(OCTA),a new and non-invasive technology,has made its breakthroughs in angiography resolution,vascular depth and vascular morphology,and it can provide objective quantitative data.It has certain application value in diabetic microangiopathy.Therefore,the purpose of this paper is to review OCTA and its application in diabetic microangiopathy.