甲状腺手术全麻诱导中盐酸羟考酮注射液对甲状腺手术患者血压、心率及BIS的影响

Effect of Oxycodone Hydrochloride Injection on Blood Pressure,Heart Rate and BIS in Patients Undergoing Thyroid Surgery During General Anesthesia Induction

目的探讨盐酸羟考酮注射液在甲状腺手术患者全麻诱导中的效果及对患者血压、心率及BIS的影响。方法选取2018年1月~2020年6月我院住院治疗的100例甲状腺手术患者作为研究对象,按照随机数字表法分为对照组和研究组,每组50例。对照组使用硫酸吗啡+托烷司琼混合生理盐水麻醉,研究组使用盐酸羟考酮注射液+托烷司琼混合生理盐水麻醉,比较两组麻醉效果、血清氧化应激反应变化情况、血流动力学变化情况、血清炎性因子水平变化情况。结果研究组拔管后镇静评分低于对照组[(3.02±0.50)分vs(3.85±0.96)分],拔管时间、麻醉苏醒时间短于对照组[(7.22±1.90)min vs(9.92±2.33)min]、[(5.20±1.09)min vs(6.93±1.73)min],差异有统计学意义(P<0.05);术后2 h,两组SOD较术前下降,MDA、NO较术前上升,且研究组SOD高于对照组,MDA、NO低于对照组,差异有统计学意义(P<0.05);两组间麻醉诱导前、插管即刻、插管后即刻、手术结束时DBP、SBP、BIS比较,差异无统计学意义(P>0.05);两组麻醉诱导前、手术结束时HR比较,差异无统计学意义(P>0.05);研究组插管即刻、插管后即刻HR低于对照组,差异有统计学意义(P<0.05);术后2、24 h,两组TNF-α、IL-10、IL-6水平均较麻醉诱导前上升,且研究组优于对照组,差异有统计学意义(P<0.05)。结论甲状腺手术患者全麻诱导中使用盐酸羟考酮注射液,可缩短患者麻醉苏醒时间,降低氧化应激反应,对血压以及BIS的影响较小,可有效抑制术后炎症的发生,麻醉效果较好。

Objective To investigate the effect of oxycodone hydrochloride injection in the induction of general anesthesia in patients with thyroid surgery and its influence on blood pressure,heart rate and BIS.Methods A total of 100 thyroid surgery patients who were hospitalized in our hospital from January 2018 to June 2020 were selected as the research objects.According to the random number table,they were divided into a control group and a study group,with 50 cases in each group.The control group was anesthetized with morphine sulfate+tropisetron mixed saline,and the study group was anesthetized with oxycodone hydrochloride injection+tropisetron mixed saline.The anesthesia effect,changes in serum oxidative stress,and blood flow were compared between the two groups dynamic changes,changes in serum inflammatory factor levels.Results The sedation scores of the study group after extubation were lower than those of the control group[(3.02±0.50)points vs(3.85±0.96)points],and the extubation time and anesthesia recovery time were shorter than those of the control group[(7.22±1.90)min vs(9.92±2.33)min],[(5.20±1.09)min vs(6.93±1.73)min],the difference was statistically significant(P<0.05);2 h after operation,SOD of the two groups decreased compared with preoperatively,and MDA and NO were lower than preoperative Increased,and SOD of the study group was higher than that of the control group,MDA and NO were lower than the control group,the difference was statistically significant(P<0.05);DBP between the two groups before induction of anesthesia,immediately after intubation,immediately after intubation,and at the end of the operation,SBP,BIS,the difference was not statistically significant(P>0.05);the comparison of HR before induction of anesthesia and at the end of the operation,the difference was not statistically significant(P>0.05);the study group was intubated immediately and immediately after intubation HR was lower than that of the control group,the difference was statistically significant(P<0.05);at 2 and 24 h after surgery,the levels of TNF-α,IL-10,and IL-6 in the two groups increased compared to before anesthesia induction,and the study group was higher the control group,the difference was statistically significant(P<0.05).Conclusion The use of oxycodone hydrochloride injection in the induction of general anesthesia in patients with thyroid surgery could shorten the patient's awakening time from anesthesia,reduce oxidative stress,and had little effect on blood pressure and BIS.It could effectively inhibit postoperative inflammation and had a better anesthetic effect it was good.