2型糖尿病肾病患者同型半胱氨酸水平与糖脂代谢的相关性分析

Correlation Analysis Between Homocysteine Levels and Glucose and Lipid Metabolism in Patients with Type 2 Diabetic Nephropathy

目的研究2型糖尿病肾病患者血清同型半胱氨酸(Hcy)含量及其与糖脂代谢的相关性。方法选取2016年8月~2019年6月我院收治的2型糖尿病肾病患者80例设为观察组,根据血清Hcy含量(15μmol/L为标准)将糖尿病肾病患者分为Hcy正常者和Hcy偏高者,另选取同期我院体检的45例健康者设为对照组,检测两组血清Hcy含量和糖脂代谢指标[空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)和糖化血红蛋白(HbA1c)],并分析其相关性。结果观察组血清Hcy、FBG、HbAIc、TC、TG、LDL高于对照组,HDL低于对照组,差异有统计学意义(P<0.05);观察组Hcy偏高者FBG、HbAIc、TC、TG、LDL高于Hcy正常者,HDL低于Hcy正常者,差异有统计学意义(P<0.05);Pearson相关分析显示,2型糖尿病患者血清Hcy水平与HbA1c呈正相关(r=0.688,P<0.05),与FBG、TC、TG、LDL和HDL均无相关性(P>0.05)。结论2型糖尿病肾病患者血清Hcy含量较高,其含量与糖脂代谢密切相关。

Objective To study the serum homocysteine(Hcy)content in patients with type 2 diabetic nephropathy and its correlation with glucose and lipid metabolism.Methods 80 patients with type 2 diabetic nephropathy admitted to our hospital from August 2016 to June 2019 were selected as the observation group.According to the serum Hcy content(15μmol/L as the standard),the patients with diabetic nephropathy were divided into normal Hcy and Hcy for those with high levels,another 45 healthy people who were examined in our hospital during the same period were selected as the control group,and the serum Hcy content and glucose and lipid metabolism indexes of the two groups were tested[fasting blood glucose(FBG),triglycerides(TG),total cholesterol(TC),triglycerides(TG),low-density lipoprotein(LDL)and glycosylated hemoglobin(HbA1c)],and analyze their correlation.Results Serum Hcy,FBG,HbAIc,TC,TG,LDL in the observation group were higher than those in the control group,and HDL was lower than the control group,the difference was statistically significant(P<0.05);the observation group with high Hcy was FBG,HbAIc,TC,TG,LDL was higher than normal Hcy,HDL was lower than normal Hcy,the difference was statistically significant(P<0.05);Pearson correlation analysis shows that serum Hcy level in patients with type 2 diabetes is positively correlated with HbA1c(r=0.688,P<0.05),and no correlation with FBG,TC,TG,LDL and HDL(P>0.05).Conclusion The serum Hcy content of patients with type 2 diabetic nephropathy was relatively high,and its content was closely related to glucose and lipid metabolism.