不同促排卵方案治疗多囊卵巢综合征不孕症的效果

The Effect of Different Ovulation Induction Programs on the Infertility of Polycystic Ovary Syndrome

目的观察不同促排卵方案对多囊卵巢综合征不孕症患者治疗效果。方法选择2018年6月~2019年6月在我院治疗的60例多囊卵巢综合征不孕症患者,随机分为对照组和实验组,各30例。对照组采用人绝经期促性腺激素治疗,实验组在对照组基础上联合应用氯米芬治疗,比较两组临床排卵率、妊娠率、雌二醇水平、黄体生成素水平、子宫内膜厚度、成熟卵泡数及不良反应发生率。结果实验组排卵率(86.67%)、妊娠率(36.67%)分别高于对照组的63.33%、16.67%(P<0.05);实验组雌二醇、黄体生成素水平、子宫内膜厚度、成熟卵泡数均高于对照组(P<0.05);实验组不良反应发生率为6.67%,低于对照组的26.67%(P<0.05)。结论人绝经期促性腺激素联合氯米芬治疗多囊卵巢综合征不孕症疗效较好,改善排卵障碍优于单用人绝经期促性腺激素,有助于提高妊娠率,且临床不良反应发生率低,安全可行。

Objective To observe the effects of different ovulation induction programs on infertility patients with polycystic ovary syndrome.Methods A total of 60 infertility patients with polycystic ovary syndrome who were treated in our hospital from June 2018 to June 2019 were selected and randomly divided into a control group and an experimental group,with 30 cases in each group.The control group was treated with human menopausal gonadotropin,and the experimental group was combined with clomiphene treatment on the basis of the control group.The clinical ovulation rate,pregnancy rate,estradiol level,luteinizing hormone level,endometrial thickness,The number of mature follicles and the incidence of adverse reactions.Results The ovulation rate(86.67%)and pregnancy rate(36.67%)of the experimental group were higher than those of the control group,63.33%and 16.67%respectively(P<0.05);the levels of estradiol and luteinizing hormone in the experimental group endometrial thickness and the number of mature follicles were higher than those of the control group(P<0.05);the adverse reaction rate of the experimental group was 6.67%,which was lower than 26.67%of the control group(P<0.05).Conclusion The combination of human menopausal gonadotropin combined with clomiphene in the treatment of infertility with polycystic ovary syndrome was effective,and it was better to improve ovulation disorders than using human menopausal gonadotropin alone,which could help increase pregnancy rate and the incidence of clinical adverse reactions was low,safe and feasible.