苗药贵州蜘蛛抱蛋镇咳抗炎作用的有效部位筛选

Screening of parts with antitussive and anti-inflammatory effects from Miao medicine Aspidistra guizhouensis

目的:对苗药贵州蜘蛛抱蛋镇咳、抗炎作用的有效部位进行筛选。方法:选择健康、体重均一、雌雄各半的昆明种小鼠,采用氨水、二氧化硫引咳制作咳嗽模型;用二甲苯致小鼠急性炎症耳肿胀,腹腔毛细血管通透性,用角叉胶致小鼠亚急性炎症足跖肿胀,观察不同提取部位的贵州蜘蛛抱蛋对镇咳、抗炎的作用。结果:苗药贵州蜘蛛抱蛋不同提取部位对咳嗽和急慢性炎症均有不同程度的抑制作用。结论:苗药贵州蜘蛛抱蛋乙酸乙酯提取部位镇咳、抗炎作用显著。

In this study we screened the parts with antitussive and anti-inflammatory effects from Miao medicine Aspidistra guizhouensis.Healthy Kunming mice with uniform weight,half male and half female were used as experimental subjects.The cough models were established with ammonia water and sulfur dioxide respectively.Acute inflammatory ear swelling was induced by xylene in mice,and subacute inflammatory paw swelling was induced by carrageenan in mice.The peritoneal capillary permeability of the mice was measured.Then the antitussive and anti-inflammatory effects of different extractive parts from Aspidistra guizhouensis were studied.The results showed that the parts extracted by ethyl acetate from Aspidistra guizhouensis had remarkable antitussive and anti-inflammatory effects.