自体脂肪基质血管成分的临床研究进展

Clinical Research Progress of Stromal Vascular Fraction in Autologous Adipose

自体脂肪基质血管成分(SVF)是由自体脂肪组织经过消化、过滤、离心等得到的富含脂肪来源干细胞的细胞群,近年来在组织工程和再生医学的研究中获得了广泛关注。SVF的研究经历了从阐明各种细胞类型作用机制的体外研究,到显示有效性的动物体内研究,在目前的临床研究中也取得了一定成效。但由于部分研究的病例数量有限或缺乏长期的随访和深入探索,因此病理生理机制仍处于进一步研究中。希望通过对SVF研究的深入,可以改善临床治疗的效果和方法,为SVF在临床的进一步应用提供指导。

Stromal vascular fraction(SVF)in autologous adipose is a population of cells rich in adipose stem cells by digestion,filtration,and centrifugation from autologous adipose tissue,which has gained wide attention in tissue engineering and regenerative medicine in recent years.The research about SVF has gone through from in-vitro studies that elucidate the mechanism of action of various cell types to in vivo animal studies that show effectiveness,and has achieved certain results in clinical studies.However,the number of cases of some diseases is limited,or there is a lack of long-term follow-up and in-depth exploration,so the pathophysiological mechanism is still under further study.It is hoped that the in-depth clinical research on SVF can improve the clinical treatment effect and methods,and provide guidance for the further application of SVF in clinical practice.