化疗药所致周围神经病变发生机制和治疗的研究进展

Research Progress in Pathogenesis and Treatment of Chemotherapy-induced Peripheral Neuropathy

化疗药所致周围神经病变(CIPN)是恶性肿瘤治疗可能出现的一种剂量限制性不良反应,主要表现为全身或部分肢体的感觉、运动和自主功能缺陷。CIPN的发生机制目前尚无统一定论,包括氧化应激反应、细胞核和线粒体DNA的损伤、离子通道的紊乱和轴突变性等。临床常见的引起CIPN的化疗药包括铂类化疗药、长春新碱、硼替佐米、沙利度胺和紫杉烷类,其中不同种类化疗药物所致CIPN的机制及其治疗可能不同。对CIPN的主要发生机制和治疗措施的研究将为临床CIPN的治疗提供新思路。

Chemotherapy-induced peripheral neuropathy(CIPN)is a dose-limiting adverse effect that may occur when chemotherapy is used to treat cancer,mainly manifested by sensory,motor and autonomic defects of the whole body or part of the limbs.The pathogenesis of CIPN is still unclear,and the currently discovered includes oxidative stress,damage to nuclear and mitochondrial DNA,disturbance of ion channels and axonal mutation.The common chemotherapeutic drugs causing CIPN include platinum chemotherapeutics,vincristine,bortezomib,thalidomide and taxanes,which have different mechanisms and may need different treatments.The study on the main mechanism and therapy of CIPN will provide new insights for the clinical treatment of CIPN.