抑郁症和冠心病共病的机制及治疗

Mechanism and Treatment of Comorbidity of Depression and Coronary Heart Disease

冠心病是严重威胁人类健康的心血管疾病,给全球带来了巨大的经济负担。吸烟、高血压、糖尿病、高脂血症、肥胖等均为传统心血管疾病危险因素,近年来,抑郁症的发病率逐年上升,已成为新的冠心病危险因素,受到国内外学者的广泛重视。抑郁可增加冠心病及其不良预后事件的发生风险,反之,冠心病亦可导致抑郁症发病率的增加,但两者的共病机制尚未完全阐明。抗抑郁治疗不能降低合并抑郁的冠心病患者的全因死亡率,但有助于抑郁症状的缓解和患者生活质量的提高,故建议采取多种临床干预措施进行抗抑郁治疗。

Coronary heart disease is a serious threat to human health,which brings a huge economic burden to the world.Smoking,hypertension,diabetes,hyperlipidemia,obesity and so on are all traditional cardiovascular risk factors.In recent years,the incidence of depression has been increasing year by year.It has become a new risk factor for coronary heart disease and has attracted extensive attention from scholars at home and abroad.Depression can increase the risk of coronary heart disease and adverse prognostic events.Conversely,coronary heart disease can also lead to an increase in the incidence of depression,but the comorbidity mechanism of the two diseases has not been fully elucidated.Antidepressant treatment cannot reduce the all-cause mortality of patients with coronary heart disease,but it can help to alleviate the depression symptoms and improve the quality of life of the patients,so it is suggested to take a variety of clinical interventions as antidepressant treatment.