糖尿病患者免疫功能状态对肺部感染的影响

Effect of Immune Function Status on Lung Infection in Patients with Diabetes

糖尿病为世界范围内发病率最高的疾病之一,严重影响人类健康,好发于中老年人群,且发病率呈上升趋势。肺部感染是临床工作中最常见的感染性疾病之一,糖尿病患者发生肺部感染的可能性以及发生肺部感染后的病死率均显著高于非糖尿病患者。长期高血糖症可影响人体的免疫功能,且长期高糖环境适宜病原菌侵入、繁殖等。高血糖和感染两者互为因果,高血糖状态使患者易发生感染或感染加重,而感染又使血糖值难以控制。与非糖尿病患者相比,糖尿病患者面临的各种严重浸润性感染的风险更高。

Diabetes is one of the diseases with the highest incidence in the world,which seriously affects human health.It more occurs in the middle-aged and elderly people,and its incidence is on the rise.Pulmonary infection is one of the most common infectious diseases in clinical work.The possibility of pulmonary infection and the fatality after pulmonary infection in diabetic patients are significantly higher than those in non-diabetic patients.Long-term hyperglycemia can affect the immune function of the human body,and the long-term high-sugar environment is suitable for pathogens to invade and multiply.Hyperglycemia and infection cause and effect each other:hyperglycemia makes patients prone to infection or aggravation of infection,and infection makes blood sugar level hard to control.Compared with non-diabetic patients,the diabetic patients are at higher risk of various serious invasive infections.