Leber遗传性视神经病神经影像研究进展

Neuroimaging research progress in Leber hereditary optic neuropathy

Leber遗传性视神经病(LHON)是线粒体脱氧核糖核酸突变导致的以无痛性视力进行性下降或丧失为主要临床表现的遗传性神经系统疾病。近年来,光学相干断层成像和磁共振成像等影像技术已用于揭示LHON神经损伤,为LHON的防治提供了潜在的影像学标记。综述神经影像学在LHON前视路与脑组织的结构和功能损伤中的最新研究进展。

Leber hereditary optic neuropathy(LHON)is a hereditary neurological disorder characterized by point mutation in mitochondrial DNA,which cause progressive painless vision loss.Recently,imaging techniques such as optical coherence tomography and magnetic resonance imaging have been used to detect the neuronal damages caused by LHON,which provides potential imaging biomarkers for the prevention and treatment of LHON.This paper systematically reviews the latest neuroimaging progress about the damage of the anterior visual pathway and brain tissues.