PSMA小分子抑制剂在前列腺癌PET/CT成像中的应用

Application of PSMA small molecule inhibitors in PET/CT imaging of prostate cancer

前列腺癌(PCa)细胞表面大多存在前列腺特异性膜抗原(PSMA)的高表达,其表达水平与肿瘤侵袭性呈正相关。PSMA PET/CT用于PCa成像具有较高的诊断敏感性及特异性,可用于初诊PCa病人的分期、指导活检和治疗、评估疗效及监测生化复发。综述不同放射性核素标记的PSMA小分子抑制剂的特点,及其在PET/CT成像及PCa临床应用方面的优缺点,以利于根据不同病人的疾病特点选择不同的PSMA小分子抑制剂进行精准诊疗。

Prostate specific membrane antigen(PSMA)is highly expressed on almost all prostate cancer(PCa)cells.Its expression level is positively correlated with tumor invasion.PSMA PET/CT has high sensitivity and specificity for PCa diagnosis,and can be applied in staging newly diagnosed PCa,guiding biopsy and treatment,evaluating efficacy and monitoring biochemical recurrence.The characteristics of various radionuclide labeled PSMA small molecule inhibitors,as well as their advantages and disadvantages in PET/CT imaging and PCa clinical application,which were reviewed to facilitate the selection of appropriate tracers for accurate diagnosis and treatment according to various purposes.