介孔碳材料CMK-3及改性介孔碳材料N,O-CMK-3对药物的吸附和释放性能

Study on drug adsorption and release properties of mesoporous carbon materials(CMK-3)and modified mesoporous carbon materials(N,O-CMK-3)

以有序介孔碳材料CMK-3为碳骨架,通过硝酸(HNO 3)氧化并将三聚氰胺作为氮源采用热解技术成功制备了氮氧共掺杂介孔碳N,O-CMK-3,通过扫描电子显微镜(SEM)、透射电子显微镜(TEM)、X射线衍射仪(XRD)、N2吸附-脱附、X射线光电子能谱(XPS)、拉曼光谱(Raman)和接触角测试对CMK-3和N,O-CMK-3材料的微观形貌、结构、组成及润湿性能进行了分析表征,测试了介孔碳材料对难溶性抗肿瘤药物羟基喜树碱(hydroxycamptothecin,HCPT)的吸附和释放性能。结果表明:经过改性后N,O-CMK-3的孔结构发生了变化,比表面积和孔体积减少,表面的含氮、氧官能团增加,介孔碳材料的表面润湿性得到改善,使得介孔碳材料的接触角由161.9°降低至138°。CMK-3和N,O-CMK-3对HCPT具有较好的吸附能力,饱和吸附量分别为811.11 mg g^-1和805.93 mg g^-1,介孔碳材料因具有纳米孔道结构提高了原料药羟基喜树碱的溶出度,负载于介孔碳材料后溶出率由22.7%提高为76.43%和72.66%。

Taking ordered mesoporous carbon material CMK-3 as the carbon skeleton,Nitric acid oxidation and melamine as nitrogen source,nitrogen oxygen co-doping mesoporous carbon N,O-CMK-3 were successfully prepared by pyrolysis technology.Scanning electron microscope(SEM),Transmission electron microscope(TEM),X-ray diffraction(XRD),N 2 adsorption-desorption,X-ray photoelectron spectroscopy(XPS),Raman spectroscopy(Raman)and contact angle test were adopted to analyze and characterize the microstructure,morphology,chemical composition and wettability of CMK-3 and N,O-CMK-3,The adsorption and release performance of the insoluble antitumor drug hydroxycamptothecin(HCPT)on the mesoporous carbon materials was tested.The results showed that the specific surface area and pore volume of modified N,O-CMK-3 decreased,and the contents of nitrogen and oxygen on the surface in functional groups increased,which improved the surface wettability and reduced the contact angle of mesoporous carbon materials from 161.9°to 138°.The mesoporous carbon materials CMK-3 and N,O-CMK-3 possessed a good adsorption capacity for hydroxycamptothecin(HCPT),and the saturated adsorption capacity was 811.11 mg g^-1 and 805.93 mg g^-1,respectively.The mesoporous carbon materials with nano-pore structure improved the dissolution rate of hydroxycamptoacine.The dissolution rate of hydroxycamptoacine loaded on mesoporous carbon materials increased from 22.7%to 76.43%and 72.66%.