溶血磷脂在慢性阻塞性肺疾病中的研究进展

Recent advances in study of lysophospholipids on chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)是呼吸系统中的常见病,其临床表现为呼吸困难、慢性咳嗽、咳痰,以持续气流受限为特征。因肺功能进行性减退,严重影响患者的劳动力和生活质量,造成巨大的社会和经济负担。因此COPD的早诊断早治疗以及开发新的治疗靶点意义重大。溶血磷脂作为重要的信号传递介质,与气道慢性炎症、氧化应激、细胞凋亡、肺组织纤维化等COPD病生理过程密切相关,有望成为COPD临床标志物及治疗靶点。

Chronic obstructive pulmonary disease(COPD)is a common disease and its clinical manifestations are dyspnea,chronic cough,expectoration,and is characterized by persistent airflow restriction.The progressive decline in lung function,seriously affecting the patient′s quality of life,resulting in a huge social and economic burden.Therefore,the early diagnosis and treatment of COPD and the development of new therapeutic targets are of great significance.As an important signaling mediator,lysophospholipid is closely related to the patholohy of COPD such as chronic airway inflammation,oxidative stress,apoptosis and pulmonary fibrosis,which is expected to become a clinical marker and therapeutic target for COPD.