中药多糖成分前处理及检测方法研究进展

Research Progress on Pretreatment and Analysis Methods for Polysaccharides in Traditional Chinese Medicine

多糖是中药的重要活性成分之一,具有降血脂、降血糖、增强免疫、抗肿瘤、抗氧化、抗凝血、抗炎症、抗衰老等活性。该类物质具有极性强、分子量大、结构难确证等特点,成为中药多糖新药开发的瓶颈。该文综述了近10年关于中药多糖成分的前处理及检测方法,以期为中药多糖定性定量分析,质量控制的提高,多糖药物深度开发和中药物质基础的全面研究提供参考。

Polysaccharides are one of the important active ingredients in traditional Chinese medicine,which have hypolipidemic,hypoglycemic,immune-enhancing,anti-tumor,antioxidant,anticoagulant,anti-inflammatory,anti-aging activities,etc.It has become a bottleneck for development of new polysaccharide medicines in traditional Chinese medicine as they contain the characteristics of strong polarity,large molecular weight and difficult to confirm for structure.The pretreatment and analysis methods for polysaccharides in traditional Chinese medicine are reviewed in this article,aiming to provide references for qualitative and quantitative analysis of polysaccharide components in traditional Chinese medicine,improvement of quality control,in-depth development of polysaccharide medicines and comprehensive research on the substance basis of traditional Chinese medicine.