低分子肝素联合加贝酯治疗高脂血症性胰腺炎疗效分析

Efficacy analysis of low-molecular weight heparin combined with gabexate in the treatment of hyperlipidemia pancreatitis

目的探索低分子肝素联合加贝酯治疗高脂血症性胰腺炎的疗效。方法120例高脂血症性胰腺炎患者,采用单双号随机化分组法分为观察组和对照组,每组60例。对照组采用加贝酯治疗,观察组在对照组基础上加用低分子肝素治疗。比较两组患者实验室指标(血淀粉酶、总胆固醇、甘油三酯)水平;各指标(血淀粉酶活性、尿淀粉酶活性、胃肠功能)恢复时间以及住院时间;炎症反应指标[白介素-8(IL-8)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平;临床疗效。结果观察组血淀粉酶(128.75±11.21)U/L、总胆固醇(5.26±1.34)mmol/L、甘油三酯(2.63±1.14)mmol/L均低于对照组的(315.48±14.58)U/L、(10.57±1.62)mmol/L、(5.89±1.25)mmol/L,差异均有统计学意义(P<0.05)。观察组血淀粉酶活性恢复时间、尿淀粉酶活性恢复时间、胃肠功能恢复时间以及住院时间均短于对照组,差异均有统计学意义(P<0.05)。观察组IL-8、IL-6、TNF-α、CRP水平均优于对照组,差异均有统计学意义(P<0.05)。观察组总有效率98.33%高于对照组的75.00%,差异有统计学意义(P<0.05)。结论对高脂血症性胰腺炎患者实施低分子肝素联合加贝酯治疗效果显著。

Objective To discuss the efficacy of low-molecular weight heparin combined with gabexate in the treatment of hyperlipidemia pancreatitis.Methods A total of 120 patients with hyperlipidemia pancreatitis were divided into observation group and control group according to odd and even number randomization grouping method,with 60 cases in each group.The control group was treated with gabexate,and the observation group was treated with low-molecular weight heparin on the basis of the control group.The laboratory indicators(blood amylase,total cholesterol,TG),indicators(blood amylase activity,urine amylase activity,gastrointestinal function)recovery time,hospitalization time,inflammatory response indexes[interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C reactive protein(CRP)]levels and clinical efficacy were compared between the two groups.Results The blood amylase(128.75±11.21)U/L,total cholesterol(5.26±1.34)mmol/L,triglyceride(2.63±1.14)mmol/L of the observation group were lower than those of the control group(315.48±14.58)U/L,(10.57±1.62)mmol/L and(5.89±1.25)mmol/L,and the difference was statistically significant(P<0.05).The recovery time of blood amylase activity,urine amylase activity,gastrointestinal function and hospitalization time of the observation group were shorter than those of the control group,and the difference was statistically significant(P<0.05).The levels of IL-8,IL-6,TNF-αand CRP of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).The total effective rate 98.33%of the observation group was higher than that of the control group 75.00%,and the difference was statistically significant(P<0.05).Conclusion Low-molecular weight heparin combined with gabexate shows remarkable therapeutic effect on patients with hyperlipidemia pancreatitis.