不同剂量瑞舒伐他汀的短期降脂效果及不良反应探究

Study on the short-term lipid-lowering effects and adverse reactions of different doses of rosuvastatin

目的探究不同剂量瑞舒伐他汀的短期降脂效果及不良反应发生情况。方法50例血脂偏高患者,根据瑞舒伐他汀用药剂量的不同分为低剂量组和高剂量组,每组25例。两组患者均给予瑞舒伐他汀,低剂量组给予10 mg/d,高剂量组给予20 mg/d。比较两组患者短期降脂效果及不良反应发生情况。结果治疗后,两组患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前下降,高密度脂蛋白胆固醇(HDL-C)水平较治疗前上升,且高剂量组的TC、TG、LDL-C水平低于低剂量组,HDL-C水平高于低剂量组,差异具有统计学意义(P<0.05)。高剂量组不良反应发生率36%高于低剂量组的12%,差异具有统计学意义(P<0.05)。结论高剂量瑞舒伐他汀(20 mg/d)的短期降脂效果更为确切,但用药后不良反应发生率较高,临床用药应根据患者病情合理选择用药剂量。

Objective To investigate the short-term lipid-lowering effects and adverse reactions of different doses of rosuvastatin.Methods A total of 50 patients with hyperlipidemia were divided into low-dose group and high-dose group according to the different dosage of rosuvastatin,with 25 cases in each group.Both groups received rosuvastatin for treatment,with 10 mg/d in the low-dose group and 20 mg/d in the high-dose group.The short-term lipid-lowering effects and occurrence of adverse reactions were compared between the two groups.Results After treatment,the total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C)of the two groups were lower than those before treatment,and high-density lipoprotein cholesterol(HDL-C)was higher than that before treatment.TC,TG and LDL-C of high-dose group were lower than those of low-dose group,and HDL-C was higher than that of low-dose group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 36%of high-dose group was lower than that of low-dose group 12%,and the difference was statistically significant(P<0.05).Conclusion High-dose rosuvastatin(20 mg/d)has more accurate short-term lipid-lowering effect,but the incidence of adverse reactions is high,so the dosage of rosuvastatin should be selected according to the patient’s condition.