2型糖尿病患者经磷酸西格列汀治疗的临床效果及其对血糖水平的影响

The clinical effect of sitagliptin phosphate treatment in type 2 diabetes mellitus patients and its influence on blood glucose level

目的分析磷酸西格列汀治疗2型糖尿病患者的疗效及其对血糖水平的影响。方法88例2型糖尿病患者,根据随机数字表法分为对照组和分析组,每组44例。对照组予以二甲双胍+阿卡波糖常规治疗,分析组在对照组的基础上加用磷酸西格列汀治疗。比较两组疗效、血糖控制情况(空腹血糖、餐后2 h血糖、糖化血红蛋白)、体质量指数(BMI)、不良反应发生率。结果分析组治疗总有效率95.5%高于对照组的79.5%,差异具有统计学意义(P<0.05)。分析组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白水平分别为(5.9±0.8)mmol/L、(8.0±0.9)mmol/L、(6.7±0.3)%,均低于对照组的(7.7±1.3)mmol/L、(10.1±1.5)mmol/L、(7.6±0.7)%,差异具有统计学意义(P<0.05)。治疗后,分析组患者BMI(24.0±2.8)kg/m^2低于对照组的(27.8±2.5)kg/m^2,差异具有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(χ^2=0.124,P=0.725>0.05)。结论对2型糖尿病患者应用磷酸西格列汀治疗可取得很好的疗效,有助于降低血糖水平和体质量,且治疗安全性较高,建议将这一治疗方案在临床中推广应用。

Objective To analyze the efficacy of sitagliptin phosphate treatment in type 2 diabetes mellitus patients and its influence on blood glucose level.Methods A total of 88 cases of type 2 diabetes mellitus patients were divided into control group and analysis group according to random numerical table,with 44 cases in each group.The control group was treated with conventional therapy of metformin and acarbose,and the analysis group was treated with sitagliptin phosphate on the basis of the control group.The efficacy,blood glucose control(fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin),body mass index(BMI)and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment 95.5%of the analysis group was higher than that of the control group 79.5%,and the difference was statistically significant(P<0.05).The fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin of the analysis group were(5.9±0.8)mmol/L,(8.0±0.9)mmol/L and(6.7±0.3)%,which were lower than those of the control group(7.7±1.3)mmol/L,(10.1±1.5)mmol/L and(7.6±0.7)%,and the difference was statistically significant(P<0.05).After treatment,BMI(24.0±2.8)kg/m^2 of the analysis group was lower than that of the control group(27.8±2.5)kg/m^2,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(χ^2=0.124,P=0.725>0.05).Conclusion Sitagliptin phosphate shows good efficacy for patients with type 2 diabetes mellitus,which can help reduce blood glucose levels and body mass with high treatment safety.It is suggested that this treatment scheme should be popularized and applied in clinical practice.