LMP-1与CXCR4在鼻咽癌组织中的表达及临床意义

Expression and Clinical Significance of LMP-1 and CXCR4 in Nasopharyngeal Carcinoma

目的探讨LMP-1、CXCR4在鼻咽癌中的表达、相关性和临床意义。方法应用免疫组化检测LMP-1及CXCR4在66例鼻咽癌组织中的表达,分析其与患者临床特点及预后的关系,并探讨两者间的关系。结果LMP-1和CXCR4阳性表达率分别为75.76%和98.48%。LMP1与CXCR4表达无相关性。CXCR4表达与临床病理因素、预后均无关。LMP-1表达与患者N分期、颈部转移淋巴结体积和有无远处转移有关(P<0.05)。生存分析发现:LMP-1是影响鼻咽癌患者总生存、无进展生存和无远处转移生存的预后因素,LMP-1阳性的鼻咽癌患者预后差。结论LMP-1可作为预测鼻咽癌远处转移的重要分子标志物。CXCR4在鼻咽癌中的价值有待进一步探讨。

Objective To investigate the expression and clinical significance of LMP-1 and CXCR4 in nasopharyngeal carcinoma and their relevance.Methods The expression of LMP-1 and CXCR4 in 66 cases of nasopharyngeal carcinoma tissues were detected by immunohistostaining.Chi-square test was conducted to analyze the associations of the expressions of LMP-1 and CXCR4 proteins with the clinicopathological features of NPC patients.Spearman rank correlation analysis was used to analyze the correlation between the LMP-1 protein expression and CXCR4 protein expression.Survival data were analyzed by Kaplan-Meier method.Results The expression rates of LMP-1 and CXCR4 was 75.76%(50/66)and 98.48%(65/66).The expression of CXCR4 was not correlated with LMP-1 expression(P>0.05).The expression of CXCR4 was not related to age,tumor size,clinical stage,metastatic lymph nodal fusion and metastatic lymph nodal necrosis(P>0.05).The expression of LMP-1 is associated with N stage and tumor volume of cervical metastatic lymph nodes.Furthermore,patients with LMP1-positive tumors had a significantly worse prognosis than patients with LMP1-negative primary tumors(P<0.05).Conclusion The findings indicated that LMP-1 might be prognosis factor for distant metastasis in NPC patients.The value of CXCR4 in nasopharyngeal carcinoma needs to be further explored.