TSH及TG水平对甲状腺癌病程及预后评估价值

The Value of TSH and TG Levels in Evaluating the Course and Prognosis of Thyroid Cancer

目的探讨促甲状腺素(TSH)及甲状腺球蛋白(TG)水平对甲状腺癌病程及预后评估中的应用价值。方法选择接受治疗的144例甲状腺癌患者为研究组,选取50例良性甲状腺病变患者为良性病变组,选取同期接受体格检查的50例健康个体为对照组,分别检测其血清TSH及TG水平,将研究组患者分别按照病程及随访12个月预后分组,对比各组间患者血清TSH及TG水平。结果研究组患者TSH及TG水平明显高于良性病变组(P<0.05),良性病变组明显高于对照组(P<0.05);随着甲状腺癌患者病程的加重,其血清TSH和TG水平也呈现逐步上升趋势,Ⅲ期、Ⅳ期患者血清TSH及TG水平明显高于Ⅰ期和Ⅱ期(P<0.05),Ⅰ期与Ⅱ期对比差异无统计学意义(P>0.05);随访12个月发现,甲状腺癌死亡组患者(21例)血清TSH及TG水平明显高于存活组(123例)患者(P<0.05)。结论TSH及TG水平与甲状腺癌患者病程及预后具有密切的相关性,患者TSH及TG水平越高,其病变就越严重,预后越差。

Objective To explore the application value of thyroid stimulating hormone(TSH)and thyroglobulin(TG)levels in the evaluation of thyroid cancer disease course and prognosis.Methods 144 patients with thyroid cancer who were selected as the study group.50 patients with benign thyroid disease were selected as benign lesions group.50 patients who underwent physical examination during the same period were selected as the control group.The serum TSH and TG levels were detected respectively.The patients in the study group were divided according to the course of disease and the prognosis after 12-month follow-up.The serum TSH and TG levels were compared between the groups.Results The levels of TSH and TG in the study group were significantly higher than those in the benign lesion group(P<0.05),and the benign lesion group were significantly higher than those of the control group(P<0.05).With the worsening of the course of thyroid cancer patients,the serum TSH and TG levels also gradually increased.The levels of serum TSH and TG in patients with stageⅢand stageⅣwere significantly higher than those in stageⅠand stageⅡ(P<0.05).There was no statistically significant difference in period comparison between stageⅠand stageⅡ(P>0.05).After 12 months of follow-up,the serum TSH and TG levels in the thyroid cancer death group(21 cases)were significantly higher than those in the survival group(123 cases)(P<0.05).Conclusion The levels of TSH and TG are closely related to the course and prognosis of patients with thyroid cancer.The higher TSH and TG levels,the more serious the lesion and the worse the prognosis.