新型冠状病毒肺炎患者核酸阳性持续时间延长可能与合并糖尿病相关

Prolonged duration of positive virus-PCR results in patients with COVID-19 may be associated with diabetes mellitus

目的:了解糖尿病与新型冠状病毒肺炎(COVID-19)临床特征的相关性。方法:以沈阳市第六人民医院收治的50例COVID-19患者为研究对象,按是否合并糖尿病分组,比较住院天数、核酸阳性持续时间、细菌感染情况、发热持续时间、肝损害及心肌损害情况等指标。结果:糖尿病组和对照组的平均住院天数分别为(24.0±6.8)天和(18.4±5.9)天;核酸阳性持续时间分别为(16.0±4.5)天和(12.3±4.4)天,均有统计学差异( P<0.05)。糖尿病组在细菌感染率、重症率、肝损害率及心肌损害率方面有增高趋势,但差异无统计学意义( P>0.05)。 结论:COVID-19患者核酸阳性持续时间延长以及住院时间延长可能与合并糖尿病相关。

Objective To investigate the correlation between concomitant diabetes mellitus and clinical features in patients with COVID-19.Methods Fifty patients with COVID-19 admitted to the Sixth People′s Hospital of Shenyang were divided into 2 groups with and without diabetes mellitus.Indexes such as hospitalization days,duration of positive virus-PCR result,secondary infection,duration of fever,rate of liver dysfunction,and rate of cardiac injury were compared between 2 groups.Results The average hospitalization durations of diabetes group and control group were(24.0±6.8)and(18.4±5.9)days,respectively,and the duration of positive virus-PCR testing results were(16.0±4.5)and(12.3±4.4)days respectively,suggesting longer hospital stay and longer time for virus clearance in the diabetes group than those in the control group(both P<0.05).The rates of secondary infection,severe subtype,liver dysfunction and cardiac injury in the diabetes group increased,though without significant difference(P>0.05).Conclusion Prolonged duration of positive virus-PCR result and average days of hospitalization in patients with COVID-19 may be associated with diabetes mellitus.