中国南方汉族不同部位结核患者与健康人群之间的性别分布差异研究

Gender distribution of different kinds of tuberculosis patients and healthy population in Han population in southern China

目的研究中国南方汉族人群中累及不同部位的结核患者与健康人群之间的性别分布差异。方法连续收录2009年1月至2019年1月中国南方地区新发结核病患者为病例组及健康志愿者为对照组。按结核累及部位对患者进行分层,分析各组人群中性别、年龄差异,计算比值比(OR)及95%可信区间(CI)。结果共纳入符合条件的结核病患者344例(单纯脊髓脊柱结核患者120例,单纯肺结核患者175例,多发结核患者49例),健康志愿者350例。病例组中男性比例高于对照组(P<0.001,OR=1.285)。单纯肺结核(OR=1.440)和多发结核患者(OR=1.306)中男性比例显著高于对照组(P<0.05),单纯脊髓脊柱结核患者中女性比例显著高于单纯肺结核患者(P<0.05,OR=1.696),但尚不能认为单纯脊髓脊柱结核患者与对照组间存在性别差异(P=0.636)。结论男性是罹患肺结核及多发结核的危险因素,女性则更容易进展为脊髓脊柱结核。

【Objective】To explore the Gender distribution of different kinds of tuberculosis(TB)patients and healthy population in Han population in southern China.【Methods】Healthy volunteers and patients with tuberculosis were enrolled between January 2009 and January 2019.The patients were divided into different groups according to the site of tuberculosis.The age and gender frequencies were compared between different groups.The odds ratio and 95%confident interval were also calculated.【Results】A total of 344 TB patients and 350 ethnicity-matched healthy controls were included.The proportion of male patients with tuberculosis was higher than that of the normal population(P<0.001,OR=1.285).The proportion of males in the patients with simple pulmonary tuberculosis(PTB)or multiple tuberculosis(MTB)was significantly higher than that of the normal population.The proportion of females in the patients with simple spinal tuberculosis(STB)was significantly higher than that of the PTB patients(P<0.05,OR=1.696).It revealed no difference in gender between the STB patients and controls(P=0.636).【Conclusion】Male is the risk factors for PTB and MTB,but female is more likely to progress to STB.