m6aRNA甲基化在肝细胞癌中的研究进展

Study advances of m6aRNA methylation and liver cancer

肝细胞癌(HCC)是全球病死率排名第四的恶性肿瘤,目前对于HCC发生发展机制尚不完全了解,患者预后较差,手术介入等治疗方式往往给患者带来较大损伤且未必能有效延长患者生存时间,寻找HCC新的干预靶点,可以更好地理解HCC发生机制和造福患者。m6aRNA甲基化是一种新兴的在真核细胞中最常见的RNA修饰。目前已经发现m6aRNA甲基化在多种人体生命活动中起重要作用,且参与包括HCC在内的多种肿瘤的发生发展,是一种新的HCC干预靶点,但在某些方面仍存在争议,该文综述了m6aRNA甲基化在HCC治疗中的相关最新研究进展并提出一些笔者的看法。

Hepatocellular carcinoma(HCC)is the fourth ranked malignant tumor in the world.At present,the mechanism of HCC occurrence and development is not fully understood.The prognosis of patients is poor.Surgical treatment method often brings great damage to patients and may not be effectively prolong the survival time of patients.Finding new targets for HCC intervention can better understand the mechanism of HCC occurrence and benefit patients.m6aRNA methylation is a new and most common RNA modification in eukaryotic cells.It has been found that the methylation of m6aRNA plays an important role in a variety of human life activities,and is involved in the occurrence and development of a variety of tumors,including HCC.It is a new target for HCC intervention,but it is still controversial in some aspects.This paper reviewed the latest research progress of the m6aRNA methylation in the treatment of HCC,and puts forward some views of its own.