大麻素2型受体在缺血性卒中中的研究进展

Advances in the treatment of ischemic stroke with cannabinoid type 2 receptors

缺血性卒中可导致严重的中枢神经系统损伤,病死率高,且预后差。大麻素2型受体不仅分布在外周免疫器官和细胞中,在脑中也具有一定的表达和功能。研究表明,大麻素2型受体在缺血性卒中的损害机制中发挥了重要的作用。该文对近年来大麻素2型受体在缺血性脑损害中的研究进展进行综述,以期为缺血性卒中寻求新的治疗靶点提供科学依据。

Ischemic stroke can lead to severe central nervous system damage,high mortality,and poor prognosis.Cannabinoid type 2 receptors are not only distributed in the peripheral immune organs and cells,but also have certain expression and function in the brain.Studies have shown that cannabinoid type 2 receptors play an important role in the injury mechanism of ischemic stroke.The paper reviews the recent research progress of cannabinoid type 2 receptors in ischemic brain injury in order to provide scientific basis for seeking new therapeutic targets for ischemic stroke.