口腔细菌影响宿主表观遗传调控的研究进展

Advances in oral bacteria influencing host epigenetic regulation

表观遗传是指非基因序列改变所导致的基因表达水平的稳定改变,微生物能通过表观遗传途径调节宿主炎症,从而逃避或者扩大免疫反应。口腔细菌作为人体微生物的重要组成部分,目前已发现多种表观遗传调控机制可影响宿主对口腔细菌的反应。本文就细菌调控表观遗传的常见途径以及不同疾病中口腔细菌对宿主表观遗传的调控进行综述,以期为口腔疾病中表观遗传相关机制研究提供参考。

Epigenetics refers to a steady change in the level of gene expression caused by non-DNA sequence changes.Microbes can modulate host inflammation through epigenetic pathways to evade or expend immune responses.As an important part of human microbes,oral bacteria also have various epigenetic regulation mechanisms to affect host inflammatory responses.This article reviews the common pathways of epigenetic regulation in microbe infection and the regulation of host epigenetics by using oral microbes to provide a reference for the study of epigenetic-related mechanisms in oral diseases.