威伐光联合卡介菌多糖核酸及液氮冷冻治疗甲周疣的临床研究

Clinical study on the treatment of periungual warts with water-filtered infrared-A combined with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy

目的观察威伐光联合卡介菌多糖核酸及液氮冷冻治疗甲周疣的临床效果。方法选择2018年1月-2019年3月于齐齐哈尔医学院附属第三医院皮肤科门诊就诊的60例甲周疣患者,按照随机数字表法将其分为对照组(29例)和治疗组(31例)。对照组利用卡介菌多糖核酸及液氮冷冻治疗,治疗组在对照组治疗基础上加威伐光局部照射治疗。观察两种方法的治疗效果及其对血清CD4^+、CD8^+及白细胞介素-2(IL-2)的影响。结果治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD4^+,CD4^+/CD8^+,IL-2水平均较治疗前升高,且治疗组高于对照组,差异均有统计学意义(均P<0.05)。两组CD8^+水平比较,差异无统计学意义(P>0.05)。对照组术后均出现不同程度的水肿和疼痛,部分患者甚至出现水疱,而治疗组术后无明显不良反应,两组不良反应发生率比较,差异有统计学意义(P<0.05)。结论卡介菌多糖核酸及液氮冷冻治疗甲周疣后联合威伐光局部照射,可明显改善机体的免疫反应,促进患者病情康复,此联合治疗方法值得临床推广。

Objective To observe the clinical effect of water-filtered infrared-A combined with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy in the treatment of periungual warts.Methods From January 2018 to March 2019,60 patients with periungual warts who admitted to the Outpatient Department of Dermatology of the Third Affiliated Hospital of Qiqihar Medical University were selected and divided into control group(29 cases)and treatment group(31 cases)according to the random number table method.The control group was treated with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy,and the treatment group was treated by local irradiation with water-filtered infrared-A on the basis of the control group.The clinical effects of the two methods and their effects on serum CD4^+,CD8^+and interleukin-2(IL-2)were observed.Results The total effective rate of the treatment group was higher than that of the control group,with statistically significant difference(P<0.05).After treatment,the levels of CD4^+,CD4^+/CD8^+and IL-2 in both groups were increased compared with those before treatment,and the levels in the treatment group were higher than those in the control group,with statistically significant differences(all P<0.05).There was no significant difference in CD8^+level between the two groups(P>0.05).In the control group,edema and pain occurred to different degrees after surgery,and some patients even appeared blisters.While in the treatment group,there were no significant postoperative adverse reactions.The incidence of adverse reactions between the two groups was statistically significant(P<0.05).Conclusion The combination of BCG polysaccharides nucleic acid and liquid nitrogen cryotherapy combined with local irradiation of water-filtered infrared-A can significantly improve the immune response of the body and promote the illnessrehabilitation of patients.This combination therapy method is worthy of clinical promotion.