丁苯酞联合阿加曲班治疗急性脑梗死患者的临床效果

Clinical effects of Butylphthalide combined with Argatroban in treatment of patients with acute cerebral infarction

目的:观察丁苯酞联合阿加曲班治疗急性脑梗死(ACI)患者的临床效果。方法:选取204例ACI患者作为研究对象,采用随机数字表法分为研究组和对照组各102例。两组均进行常规治疗,对照组在此基础上使用阿加曲班治疗,研究组在对照组基础上联合丁苯酞氯化钠注射液治疗,比较两组治疗前后神经功能、治疗总有效率和不良反应发生率。结果:治疗后,研究组美国国立卫生研究院卒中量表和改良Rankin量表评分均低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为93.14%(95/102),明显高于对照组的73.53%(75/102),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丁苯酞联合阿加曲班治疗ACI患者,可降低神经功能评分,提高治疗总有效率,其效果优于单纯阿加曲班治疗效果。

Objective:To observe clinical effects of Butylphthalide combined with Argatroban in treatment of acute cerebral infarction(ACI).Methods:204 ACI patients were selected as the research objects,and were divided into study group and control group by using the random number table method,each with 102 cases.Both groups received conventional treatment.Besides,the control group was treated with Argatroban,while the study group was treated with Butylphthalide and sodium chloride injection on the basis of that of the control group.The nerve function,treatment effective rate and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the scores of the national institutes of health stroke scale and modified Rankin scale of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The treatment effective rate of the study group was 93.14%(95/102),which was significantly higher than 73.53%(75/102)of the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Butylphthalide combined with Argatroban in the treatment of ACI patients can reduce the nerve function score and improve the treatment effective rate.Moreover,it is superior to single Argatroban.