血清CCL4水平和绝经后骨质疏松症严重程度相关性研究

Correlation between serum CCL4 level and severity of postmenopausal osteoporosis

目的探讨血清CCL4水平与绝经后骨质疏松症(PMOP)严重程度的关系。方法对66名PMOP女性,68名绝经后非骨质疏松女性和67名健康育龄妇女进行研究。用双能X射线吸收测定法扫描评估骨密度。Oswestry残疾指数和视觉模拟量表用于量化症状的活动功能和严重程度。用定量夹心酶联免疫吸附测定血清CCL4水平。结果发现CCL4血清水平与骨密度呈显著负相关。此外,血清CCL4水平与视觉模拟评分和Oswestry残疾指数评分显著相关。结论血清CCL4是评估PMOP女性疾病严重程度的潜在生物标志物。

Objective To explore the relationship between serum CCL4 level and the severity of postmenopausal osteoporosis(PMOP).Methods This research enrolled 66 PMOP females,68 post-menopausal nonosteoporotic women and 67 healthy women of childbearing age.Bone mineral densities were assessed with dual X-ray absorptiometry scans.The Oswestry disability index and the visual analog scale were employed to quantify functional ability and severity of symptoms.Serum CCL4 levels were examined with a quantitative sandwich enzyme-linked immunosorbent assay.Results We observed a significant negative correlation of CCL4 serum levels with bone mineral density.Furthermore,serum CCL4 concentrations were significantly related to the visual analog scale and Oswestry Disability Index scores.Conclusion Serum CCL4 is a potential biomarker to evaluate disease severity in PMOP females.