鸢尾素在运动改善骨代谢中的作用研究

Study on the role of irisin in improving bone metabolism by exercise

鸢尾素(Irisin)是运动介导的调控能量代谢的肌肉因子,在治疗肥胖、Ⅱ型糖尿病、脂代谢和心血管疾病、骨代谢疾病等具有良好的作用。研究发现运动可以促进鸢尾素的分泌,同时鸢尾素又可以改善骨的代谢。鸢尾素可以直接靶向成骨细胞改善骨代谢,可以调节Runx2、Atf4、Spp1、Sost等骨骼基因改善骨代谢,可以与Wnt、BMP(MAPK)、OPG/RANKL/RANK信号通路发生级联反应调控骨代谢,也可以增强有氧糖酵解来改善骨代谢。鸢尾素作为改善骨代谢新的肌肉因子,它的出现将极大地促进我们对运动改善骨健康的理解,并为药物治疗骨代谢疾病提供新线索。目前我们虽然证实了运动可以通过鸢尾素改善骨代谢,但是鸢尾素的分泌与运动类型、运动时间、运动强度、人群等因素存在复杂的关系。我们知道鸢尾素可以改善骨代谢,但是鸢尾素改善骨代谢的相关机制还需要更深入研究。骨代谢疾病的出现,迫使我们要加速了解更多合理改善骨代谢的方法。本文将从运动与鸢尾素、运动与骨代谢及鸢尾素与骨代谢方面进行综述,旨在为运动改善骨代谢疾病,骨代谢疾病治疗等方面提供参考和依据。

Irisin is a muscle factor that mediates exercise and regulates energy metabolism,it has a good effect in the treatment of obesity,type 2 diabetes,lipid metabolism,cardiovascular disease,bone metabolism disease and so on.Studies have found that exercise can promote the delivering of Irisin,while Irisin can improve bone metabolism through targeting osteoblast directly,improving the regulation of bone genes such as Runx2,Atf4,Spp1 and Sost,having cascade reaction with signaling pathways,including Wnt,BMP(MAPK),OPG/RANKL/RANK,and enhancing aerobic glycolysis as well.As a newly found myokine which works on bone metabolism,Irisin will help us understand that exercise improves bone health better.Besides,it also provides news suggestions of drug treatments for metabolic bone diseases.At present,it has been confirmed that exercise can improve bone metabolism through Irisin mediation,but there is a complex relationship between the secretion of Irisin and exercise type,exercise time,exercise intensity,population,etc.It is known that Irisin can improve bone metabolism,however,relevant studies between them still have a long way to go.The emergence of bone metabolism diseases has forced us to accelerate our understanding of more reasonable ways to improve bone metabolism.This paper summarizes the relations between exercise and Irisin,exercise and bone metabolism and Irisin and bone metabolism to provide references and basis for exercise to improve bone metabolism diseases and treatment of bone metabolism diseases.