肝细胞癌肺转移患者口服索拉非尼致4级手足综合征1例并文献复习

Hand-foot Syndrome Caused by Oral Sorafenib in A Hepatocellular Carcinoma Patient with Lung Metastases and Literature Review

患者女,59岁,在肝细胞性肝癌介入术后出现复发以及肺转移。口服索拉非尼后,出现掌跖部的红斑、水疱。患者感觉肢端麻木、肿胀伴疼痛停药后缓解,再次用药后加重,服药期间肺部检查显示病灶缩小。诊断:索拉非尼所致手足综合征。索拉菲尼片减量至200 mg,1次/d,配合维生素B6口服及凡士林软膏外用,连续用药3个月,直至肺部CT复查转移灶消失后停药。停药至今6年,未见肿瘤复发或新增转移灶。

A 59-year-old female presented recurrence and lung metastases after interventional treatment of hepatocellular carcinoma.After taking oral Sorafenib,there were erythema and blisters on the palms and plantars.She felt numbness and swelling with pain.The rashes and symptoms resolved after discontinuation and worsened after re-administration of the drug.During Sorafenib treatment,CT examination of the lung showed that the metastasis was reduced.Sorafenib-induced hand-foot syndrome was diagnosed.Combined with oral vitamin B6 and topical used Vaseline ointment was given.Sorafenib was reduced to 200 mg QD and was continuously used for 3 months until the lung CT reexamination showed that the metastasis was disappeared.No recurrence or metastasis was found after 6 years follow up.