野百合碱诱导肺动脉高压模型的机制研究及潜在临床应用价值进展

Advanced mechanisms and potential clinical application value of monocrotaline-induced pulmonary artery hypertension animal model

肺动脉高压(PAH)是以肺动脉压力和肺血管阻力升高为特征的致死性心血管疾病。野百合碱(MCT)引起的PAH病理特征和临床患者十分相似。MCT可以通过炎症反应、内皮途径以及调节肺动脉平滑肌细胞的增殖等因素诱导PAH的发生。因此本文对近几年MCT诱导PAH动物模型的作用机制以及在PAH新治疗药物靶点筛选中的应用进行简要综述。

Pulmonary artery hypertension(PAH)is a fatal cardiovascular disease characterized by increases in pulmonary artery pressure and pulmonary vascular resistance.The pathological features of PAH induced by monocrotaline(MCT)are similar to those of clinical patients.MCT-induced PAH through multiple factors including inflammatory response,endothelium pathway,and regulation of pulmonary artery smooth muscle cells proliferation,et al.Therefore,this article briefly reviews the advances molecular mechanism of the MCT-induced PAH and the exploration in the novel therapeutic targets by using this animal model in recent years.