低剂量黄体酮注射液联合保胎无忧胶囊对先兆流产产妇血清P、E2、β-hCG的影响研究

Effect study of low-dose Progesterone Injection combined with Baotai Wuyou Capsules on serum P, E2, β-hCG in pregnant women with threatened abortion

目的分析低剂量黄体酮注射液联合保胎无忧胶囊对先兆流产患者的治疗效果,及对患者血清孕激素(P)、雌二醇(E2)、β-人绒毛膜促性腺激素(β-hCG)水平的影响。方法选取2016年10月—2018年10月于辽宁省丹东市妇女儿童医院接受治疗的先兆流产产妇为研究对象,并根据随机数字表法分为对照组和观察组,每组80例。两组患者均给予低剂量黄体酮注射液治疗,观察组在此基础上给予保胎无忧胶囊治疗。观察两组治疗效果,比较两组治疗前后血清P、E2、β-hCG、免疫指标水平和不良反应发生率。结果观察组保胎成功率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗前β-hCG、P、E2水平比较,差异无统计学意义(P>0.05)。治疗后,两组β-hCG、P、E2水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组治疗前IgG、IgA、IgM水平比较,差异无统计学意义(P>0.05)。治疗后,两组IgG、IgA、IgM水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组头晕、呕吐、乳房胀痛等不良反应总发生率比较,差异无统计学意义(P>0.05)。结论低剂量黄体酮注射液联合保胎无忧胶囊对先兆流产产妇的治疗效果较好,可明显改善患者的激素水平,提高保胎成功率,具有良好的临床应用价值。

Objective To analyze the therapeutic effect of low-dose Progesterone Injection combined with Baotai Wuyou Capsules on patients with threatened abortion,and serum progesterone(P),estradiol(E2),β-human chorionic gonadotropin(β-hCG)levels.Methods The women with threatened abortion treated in Dandong Women and Children′s Hospital of Liaoning Province from October 2016 to October 2018 were selected as research subjects,and they were divided into control group and observation group according to the random number table method,with 80 cases in each group.Patients of both groups were given low-dose Progesterone Injection,and observation group was given Baotai Wuyou Capsules.Treatment effect of two groups was observed.Serum P,E2,β-hCG,immune indicators levels and incidence of adverse reactions before and after treatment of two groups were compared.Results Treatment success rate in observation group was significantly higher than that in control group(P<0.05).There were no significant differences in the levels ofβ-hCG,P and E2 between two groups before treatment(P>0.05).After treatment,the levels ofβ-hCG,P and E2 in two groups were higher than those before treatment,and observation group was higher than that control group,the differences were statistically significant(P<0.05).There were no significant differences in the levels of IgG,IgA and IgM between two groups before treatment(P>0.05).After treatment,the levels of IgG,IgA and IgM in two groups were higher than those before treatment,and observation group was higher than that control group,the differences were statistically significant(P<0.05).There were no significant differences in the total incidence of dizziness,vomiting,breast pain and other adverse reactions between two groups(P>0.05).Conclusion Low-dose Progesterone Injection combined with Baotai Wuyou Capsules has a good therapeutic effect on women with threatened abortion.It can obviously improve the hormone level of patients and increase the success rate of fertility protection.It has good clinical application value.