《景岳全书·妇人规》论治月经病组方配伍特点及学术思想研究

Research on the formula features and academic thoughts of Jingyue Quanshu·Furen Gui for treating menopathy diseases

目的系统整理《景岳全书·妇人规》“经脉类”中治疗月经病的内服方剂,探究张景岳治疗月经病的学术思想。方法以中国医药科技出版社出版的《景岳全书·妇人规》为检索源,将符合纳入标准的方剂进行整理和信息提取,并对药物和方剂进行频数分析;借助SPSS Statistic 23.0、SPSS Modeler 14.1软件分别对高频药物进行聚类分析、关联分析。结果最终得到方剂97首,所属补阵最多;共得到100味中药,其中所使用的高频药物有当归、甘草、熟地等。经聚类分析得到5个核心药物组,分别为人参、甘草;川芎、芍药;牡丹皮、泽泻;柴胡、陈皮;山药、山茱萸。通过关联分析共得到4个关联性较强的药物组合,分别为甘草与人参、当归与甘草、当归与芍药、当归与熟地。根据Apriori关联分析模型得到8对具有潜在关联规则的中药,分别为甘草与人参、甘草与白术、熟地与山药、当归与川芎、甘草与柴胡、山药与山茱萸、熟地与山茱萸、甘草与干姜。结论数据挖掘结果显示,张景岳治疗月经病时重视益气养血,尤重健脾补肾,同时扶正不忘驱邪,注重温补但不废清泻。数据挖掘结果与传统理论相吻合,合理有效。

Objective To systemically sort out the prescriptions for the treatment of menopathy diseases in“Jingmai Lei”in the Jingyue Quanshu·Furen Gui,and to explore his academic thoughts.Methods Taking the book of Jingyue Quanshu·Furen Gui published by China Medical Science Press as the retrieval source,the formulas that met the inclusion criteria were used for frequency analysis.The software of SPSS Statistic 23.0 and SPSS Modeler 14.1 were used for cluster analysis and association analysis of the high frequency drugs.Results Finally,97 prescriptions were obtained,of which,the tonifying array was the most.A total of 100 Chinese herbs were obtained,among which,the high frequency drugs included Radix Angelicae Sinensis,Radix Glycyrrhizae,Radix Rehmanniae Preparata,and so on.Five core drug groups were obtained by cluster analysis,which were Radix Ginseng and Radix Glycyrrhizae,Rhizoma Ligustici Chuanxiong and Chinese peony,Cortex Moutan Radicis and Rhizoma Alismatis,Radix Bupleuri and Pericarpium Citri Reticulatae,Rhizoma Dioscoreae and Fructus Corni.Through correlation analysis,four drug combinations with strong correlation were obtained,which were Radix Glycyrrhizae and Radix Ginseng,Radix Angelicae Sinensis and Radix Glycyrrhizae,Radix Angelicae Sinensis and Chinese peony,Radix Angelicae Sinensis and Radix Rehmanniae Preparata.According to Apriori correlation analysis model,eight groups of traditional Chinese medicine with potential association rules,which were Radix Glycyrrhizae and Radix Ginseng,Radix Glycyrrhizae and Rhizoma Atractylodis Macrocephalae,Radix Rehmanniae Preparata and Rhizoma Dioscoreae,Radix Angelicae Sinensis and Rhizoma Ligustici Chuanxion,Radix Glycyrrhizae and Radix Bupleuri,Rhizoma Dioscoreae and Fructus Corni,Radix Rehmanniae Preparata and Fructus Corni,Radix Glycyrrhizae and Rhizoma Zingiberis.Conclusion The results of data mining show that Zhang Jingyue is good at replenishing qi and nourishing blood,especially in invigorating spleen and tonifying kidney,and strengthening vital qi and eliminating pathogen in the same time,and paying attention in warming up but not eliminating heat.The result of data mining is consistent with the traditional theory,which is reasonable and effective.